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Single-Molecule & Cell Dynamics Lab

Copyright ⓒ 2009. SMCB, All Rights Reserved.

Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 08826, Korea
Tel: 82-2-880-2234




# Co-first author; *Corresponding author



A. Papers

28. O. Lee, C. Kim, J. Y. Kim, N. K. Lee*, W. Sung*, "Two conformational states in D-form DNAs: The effects of local denaturation", Scientific Reports, Published online (2016)

27. G. Shin#, D.-K. Kim#, J. Doh, D. Lee, N. K. Lee*, G. Y. Jung*, “High-Resolution Pluronic-filled Microchip CE-SSCP Analysis System via Channel Width Control”, Electrophoresis, 37, 676-679 (2016).


26. H. S. Kim, H. N. Im, D. R. An, J. Y. Yoon, J. Y. Jang, S. Mobashery, D. Hesek, M. Lee, J. Yoo, M. Cui, S. Choi, C. Kim, N. K. Lee, S.-J. Kim, J. Y. Kim, G. Bang, B. W. Han, B. I. Lee, H. J. Yoon, S. W. Suh, “The cell-shape determining Csd6 protein from Helicobacter pylori constitutes a new family of L,Dcarboxypeptidase", J. Biol. Chem. 290, 25103-25117 (2015).


25. Y. R. Lim, J.-H. Kim, S. J. Park, G.-S. Yang, S. Song, S.-K. Chang, N. K. Lee, J. Sung, “Quantitative understanding of probabilistic behavior of living cells operated by vibrant reaction networks,  Phys. Rev. X 5, 031014 (2015).​

24. C. Kim, O. Lee, J.-Y. Kim, W. Sung, N. K. Lee,* Dynamic release of bending stress in short dsDNA by a kink and forks, Angew. Chem. Int. Ed. 31, 8943-8947 (2015). **VIP paper (top 5%)

23. J.-Y. Kim, C. Kim, N. K. Lee,* “Real-time submillisecond single-molecule FRET dynamics of freely diffusing molecules with liposome tethering”,
Nature Communications 6, 6992 (2015).  * Highlighted in Nature Materials, "Single-molecule tracking Fretted diffusion" (Nature Materials 14, 556, 2015)

22. D.-H. Kim
#, K. Zhou#, D.-K. Kim#, S. Park, J. Noh, Y. Kwon, D. Kim, N. W. Song, J.-B. Lee, P.-G. Suh, N. K. Lee*, S. H. Ryu,* “Analysis of Interactions between the Epidermal Growth Factor Receptor and Soluble Ligands on the Basis of Single-Molecule Diffusivity in the Membrane of Living Cells”, Angew. Chem. Int. Ed. 24, 7028–7032(2015).

21. Y-M Soh, F. Bürmann, H-C Shin, T. Oda, K. S. Jin, C. P. Toseland, C. Kim, H. Lee, S. J. Kim, M-S Kong, M-L Durand-Diebold, Y.-G.  Kim, H. M. Kim, N. K. Lee, M. Sato, B.-H. Oh, S. Gruber, “Molecular basis for SMC rod formation and its dissolution upon DNA binding”, Molecular Cell 57, 1-14 (2015).

20. S. Yang, S. H. Kim, Y. R. Lim, C. H. Kim, H. J. An, J-H Kim, J. Sung,* N. K Lee* “Contribution of RNA polymerase concentration variation to protein expression noise”, Nature communications 5, 4761 (2014).


19. B. K Choi#, M. G. Choi#,  J.Y. Kim#,  Y. Yang, Y. Lai, D. H. Kweon, N. K. Lee,* Y. K. Shin* “Large α-Synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking”, Proc. Natl. Acad. Sci. USA 110, 4087-4092 (2013). * BRIC 2013 학술 가치가 높은 연구 성과 Top 5 선정

18. J. Y. Kim#, B. K Choi,# M. G. Choi, S. A. Kim, Y. Lai, Y. K. Shin,* N. K Lee,*  “Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs”, EMBO J. 31, 2144-2155  (2012).* BRIC 2012 학술 가치가 높은 연구 성과 Top 5 선정

17. C. H. Kim, J. Y. Kim, S. H. Kim, B. I. Lee, N. K. Lee,* “Direct characterization of protein oligomers and their quaternary structures by single-molecule FRET”, Chem. Comm. 48, 1138-1140 (2012).

16. N. K. Lee,* S. Park, M. H. Yoon, Z. H. Kim, S. K. Kim,* “Effect of ring torsion on intramolecular vibrational redistribution dynamics of 1,1’-binaphthyl and 2,2’-binaphthyl”, Phys. Chem. Chem. Phys. 14, 840-848 (2012).

15. N. K. Lee,# H. R. Koh,# K. Y. Han, J. Lee, S. K. Kim, “Single-molecule, real-time measurement of enzyme kinetics by alternating-laser excitation fluorescence resonance energy transfer”, Chem. Comm. 46, 4683 (2010). # equal contribution.

14. X. S. Xie, P. J. Choi, G-W Li, N. K. Lee, and G. Lia, “Single-Molecule Approach to Molecular Biology in Living Bacterial Cells”, Annu. Rev. Biophys. 37, 417 (2008).

13. N. K. Lee, H. R. Koh, K. Y. Han, and S. K. Kim, “Folding of 8-17 deoxyribozyme studied by three-color alternating-laser excitation of single-molecules”, J. Am. Chem. Soc. 129, 15526 (2007).

12. N. K. Lee, A. N. Kapanidis, H. R. Koh, Y. Korlann, S. O. Ho, N. Gassman, S. K. Kim, and S. Weiss, “Three-Color Alternating-Laser Excitation of Single Molecules: Monitoring Multiple Interactions and Distances”, Biophys. J. 92, 303 (2007).

* Highlighted in “Probes Light the Way for Advances in FRET”, Biophotonics, p30, February (2007).

11. J. H. Kim, N. K. Lee, S. H. Lee, S. Y. Han, and J. K. Song, “Ion core structures in anthracene anion tetramers”, Bull. Korean Chem. Soc. 27, 1453 (2006).

10. A. N. Kapanidis, T. A. Laurence, N. K. Lee, E. Margeat, X. Kong, and S. Weiss, “Alternating-Laser Excitation of Single Biomolecules”, Acc. Chem. Res. 38, 523 (2005).

9. N. K. Lee,# A. N. Kapanidis,# Y. Wang, X. Michalet, J. Mukhopadhyay, R. H. Ebright, and S. Weiss, “Accurate FRET measurements within single diffusing biomolecules using alternating-laser excitation” Biophys. J. 88, 2939 (2005).

8. N. K. Lee and S. K. Kim, Ab initio-based Intermolecular Carbon-Carbon Pair Potentials for Polycyclic Aromatic Hydrocarbon Clusters", J. Chem. Phys. (Communication) 122, 031102 (2005).

7. A. N. Kapanidis,# N. K. Lee,# E. Margeat, T. Laurence, S. Doose, and S. Weiss, “Fluorescence-Aided Molecule Sorting: analysis of structure and interactions by alternating-laser excitation of single molecules”, Proc. Natl. Acad. Sci. USA 101, 8936 (2004).

* Highlighted in (1) C&EN news, Science Concentrates, p30, June 7 (2004); (2) “Alternating-laser excitation probes structures and interactions”, Biophotonics, p52, August (2004); (3) “Single-molecule sorting”, Nat. Biotechnol. 22, 831 (2004).

6. J. K. Song, N. K. Lee, J. H. Kim, S. Y. Han, and S. K. Kim, "Anion Clusters of Anthracene, Ann- (n=1-16)”, J. Chem. Phys. 119, 3071(2003).

5. J. K. Song, N. K. Lee, and S. K. Kim, "Multiple Ion Cores in Anthracene Anion Clusters", Angew. Chem. Int. Ed. 42, 213 (2003).

4. J. K. Song, N. K. Lee, and S. K. Kim, "The Benzene-Naphthalene Anion: the Smallest Anion Complex of Aromatic Hydrocarbons", J. Chem. Phys. (Communication) 117, 9973 (2002). 

3. J. K. Song, N. K. Lee, and S. K. Kim, "Photoelectron Spectroscopy of Pyrazine Cluster Anions", J. Chem. Phys. 117, 1589 (2002).

2. N. K. Lee, S. Park, and S. K. Kim, “Ab Initio Studies on the van der Waals Complexes of Polycyclic Aromatic Hydrocarbons. II. Naphthalene Dimer and Naphthalene-Anthracene Complex", J. Chem. Phys. 116, 7910 (2002).

1. N. K. Lee, S. Park, and S. K. Kim, “Ab Initio Studies on the van der Waals Complexes of Polycyclic Aromatic Hydrocarbons. I. Benzene-Naphthalene Complex", J. Chem. Phys. 116, 7902 (2002).


B. Book chapters

1. J. Y. Kim, B. K Choi, Y. K. Shin, N. K Lee,* “Solution single-vesicle assay by alternating-laser excitation”, Exocytosis Methods, Volume 83, pp 3-22 (2014).